The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study
<b>Objectives</b>: In this single-center retrospective study, we aimed to verify the extent of duodenal follicular lymphoma (DFL) and investigate the role and clinical significance of video capsule endoscopy (VCE) in the treatment process. <b>Methods</b>: We analyzed the clin...
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MDPI AG
2025-01-01
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| author | Donghoon Kang Gi-June Min Tong Yoon Kim Young-Woo Jeon Yukyung Cho Jae Myung Park Joo Hyun O Byung-Ock Choi Gyeongsin Park Seok-Goo Cho |
| author_facet | Donghoon Kang Gi-June Min Tong Yoon Kim Young-Woo Jeon Yukyung Cho Jae Myung Park Joo Hyun O Byung-Ock Choi Gyeongsin Park Seok-Goo Cho |
| author_sort | Donghoon Kang |
| collection | DOAJ |
| description | <b>Objectives</b>: In this single-center retrospective study, we aimed to verify the extent of duodenal follicular lymphoma (DFL) and investigate the role and clinical significance of video capsule endoscopy (VCE) in the treatment process. <b>Methods</b>: We analyzed the clinical and imaging data of 40 patients diagnosed with DFL. <b>Results</b>: Imaging workup and bone marrow biopsies revealed DFL only in the gastrointestinal tract (stage I) in 22 patients and in local lymph nodes (stage II<sub>1</sub>), distant lymph nodes (stage II<sub>2</sub>), pancreas (stage II<sub>2</sub>E<sub>pancreas</sub>), and extranodal regions (stage IV) in 1, 3, 1, and 13 patients, respectively. Fifteen of the 23 patients with localized (stages I and II<sub>1</sub>) DFL underwent VCE for comprehensive small bowel evaluation, which revealed lesion extension beyond the duodenum in 10 patients (66.7%). A watch-and-wait strategy was implemented for one patient and systemic chemotherapy was administered to the remaining nine. Of the eight patients without VCE, seven and one received radiotherapy and observation, respectively. Nine of the 23 patients (39.1%) received systemic treatment based on positive VCE results. Only one of the 17 patients with advanced-stage DFL (stages II<sub>2</sub> and IV) accepted radiotherapy; 16 underwent systemic chemotherapy. During follow-up (median, 48.4 months), two relapse events occurred in the advanced stage, with no lymphoma-associated deaths. DFL tends to be indolent and has favorable outcomes. <b>Conclusions</b>: Proactive VCE for diagnosing DFL is recommended to determine small bowel involvement, which may influence subsequent treatment decisions. |
| format | Article |
| id | doaj-art-f328f73837d7497398bcc68c371abb3f |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-f328f73837d7497398bcc68c371abb3f2025-01-24T13:29:03ZengMDPI AGDiagnostics2075-44182025-01-0115219310.3390/diagnostics15020193The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective StudyDonghoon Kang0Gi-June Min1Tong Yoon Kim2Young-Woo Jeon3Yukyung Cho4Jae Myung Park5Joo Hyun O6Byung-Ock Choi7Gyeongsin Park8Seok-Goo Cho9Department of Gastroenterology and Hepatology, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of KoreaDepartment of Hematology, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of KoreaDepartment of Hematology, Catholic University Lymphoma Group, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Republic of KoreaDepartment of Hematology, Catholic University Lymphoma Group, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Republic of KoreaDepartment of Gastroenterology and Hepatology, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of KoreaDepartment of Gastroenterology and Hepatology, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of KoreaDepartment of Nuclear Medicine, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of KoreaDepartment of Radiation Oncology, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of KoreaDepartment of Hospital Pathology, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of KoreaDepartment of Hematology, Catholic University Lymphoma Group, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul 06591, Republic of Korea<b>Objectives</b>: In this single-center retrospective study, we aimed to verify the extent of duodenal follicular lymphoma (DFL) and investigate the role and clinical significance of video capsule endoscopy (VCE) in the treatment process. <b>Methods</b>: We analyzed the clinical and imaging data of 40 patients diagnosed with DFL. <b>Results</b>: Imaging workup and bone marrow biopsies revealed DFL only in the gastrointestinal tract (stage I) in 22 patients and in local lymph nodes (stage II<sub>1</sub>), distant lymph nodes (stage II<sub>2</sub>), pancreas (stage II<sub>2</sub>E<sub>pancreas</sub>), and extranodal regions (stage IV) in 1, 3, 1, and 13 patients, respectively. Fifteen of the 23 patients with localized (stages I and II<sub>1</sub>) DFL underwent VCE for comprehensive small bowel evaluation, which revealed lesion extension beyond the duodenum in 10 patients (66.7%). A watch-and-wait strategy was implemented for one patient and systemic chemotherapy was administered to the remaining nine. Of the eight patients without VCE, seven and one received radiotherapy and observation, respectively. Nine of the 23 patients (39.1%) received systemic treatment based on positive VCE results. Only one of the 17 patients with advanced-stage DFL (stages II<sub>2</sub> and IV) accepted radiotherapy; 16 underwent systemic chemotherapy. During follow-up (median, 48.4 months), two relapse events occurred in the advanced stage, with no lymphoma-associated deaths. DFL tends to be indolent and has favorable outcomes. <b>Conclusions</b>: Proactive VCE for diagnosing DFL is recommended to determine small bowel involvement, which may influence subsequent treatment decisions.https://www.mdpi.com/2075-4418/15/2/193duodenal follicular lymphomavideo capsule endoscopysmall bowelchemotherapy |
| spellingShingle | Donghoon Kang Gi-June Min Tong Yoon Kim Young-Woo Jeon Yukyung Cho Jae Myung Park Joo Hyun O Byung-Ock Choi Gyeongsin Park Seok-Goo Cho The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study Diagnostics duodenal follicular lymphoma video capsule endoscopy small bowel chemotherapy |
| title | The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study |
| title_full | The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study |
| title_fullStr | The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study |
| title_full_unstemmed | The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study |
| title_short | The Role of Small Bowel Capsule Endoscopy in Determining the Treatment Strategy for Duodenal Follicular Lymphoma: A Single-Center Retrospective Study |
| title_sort | role of small bowel capsule endoscopy in determining the treatment strategy for duodenal follicular lymphoma a single center retrospective study |
| topic | duodenal follicular lymphoma video capsule endoscopy small bowel chemotherapy |
| url | https://www.mdpi.com/2075-4418/15/2/193 |
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