Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes

Abstract Background Heme oxygenase 1 (HO-1), encoded by the HMOX1 gene is a highly inducible enzyme with multiple cardiovascular protective properties. Polymorphisms of the HMOX1 gene, especially a guanine-thymine dinucleotide repeat polymorphism (GTn), affects its transcriptional activity and is as...

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Main Authors: Heli Segersvärd, Niina Sandholm, Valma Harjutsalo, Heidi Tikkanen, Riikka Kosonen, Mika Laine, Ilkka Tikkanen, Per-Henrik Groop, Päivi Lakkisto, the FinnDiane Study Group
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cardiovascular Diabetology
Online Access:https://doi.org/10.1186/s12933-025-02895-2
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