The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease
Background: The study aims to assess the feasibility of using a combined approach of liver function indices and FibroScan measurements as a predictive tool for the early detection of anti-tuberculosis drug-induced liver injury (DILI) in patients with existing liver disease. Methods: A retrospective...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501017S.pdf |
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| author | Shaoqiang Wu Qiaohua Yang Huai Li Yongzhong Li |
| author_facet | Shaoqiang Wu Qiaohua Yang Huai Li Yongzhong Li |
| author_sort | Shaoqiang Wu |
| collection | DOAJ |
| description | Background: The study aims to assess the feasibility of using a combined approach of liver function indices and FibroScan measurements as a predictive tool for the early detection of anti-tuberculosis drug-induced liver injury (DILI) in patients with existing liver disease. Methods: A retrospective cohort study was conducted, including adult tuberculosis patients with documented liver disease. Liver function was assessed using standard biochemical parameters, and FibroScan examinations were performed to determine liver stiffness measurement (LSM). Patients were monitored for clinical and biochemical signs of DILI throughout treatment. Logistic regression models and Receiver Operating Characteristic (ROC) curves were used for data analysis. Statistical significance was set at P<0.05. Results: Patients who developed DILI showed significantly higher levels of ALT, AST, total bilirubin, GGT, and LSM, with strong positive correlations between these markers and DILI occurrence. Logistic regression analysis revealed elevated ALT, AST, TBIL, and GGT were strongly associated with an increased likelihood of DILI. The area under the ROC curves indicated excellent predictive accuracy of these parameters. A nomogram for predicting DILI based on the combined biomarkers was established. Conclusions: The study demonstrates the feasibility of combining liver function indices and FibroScan measurements to predict anti-tuberculosis DILI. The results highlight the importance of baseline liver health assessment and offer promising implications for clinical practice, aiding in individualized risk estimation and therapeutic decision-making for patients with liver disease initiating anti-tuberculosis therapy. Further validation in larger cohorts is warranted to strengthen the predictive model. |
| format | Article |
| id | doaj-art-f2dc1d4fa2054edaa29c6efcf292c6c6 |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-f2dc1d4fa2054edaa29c6efcf292c6c62025-02-05T13:11:23ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-01441172310.5937/jomb0-508781452-82582501017SThe feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver diseaseShaoqiang Wu0Qiaohua Yang1Huai Li2Yongzhong Li3Hunan University of Medicine General Hospital, Infectious Disease Center, Department of Hepatology, Huaihua, ChinaHunan University of Medicine General Hospital, Infectious Disease Center, Department of Hepatology, Huaihua, ChinaHunan University of Medicine General Hospital, Infectious Disease Center, Department of Hepatology, Huaihua, ChinaHunan University of Medicine General Hospital, Infectious Disease Center, Department of Hepatology, Huaihua, ChinaBackground: The study aims to assess the feasibility of using a combined approach of liver function indices and FibroScan measurements as a predictive tool for the early detection of anti-tuberculosis drug-induced liver injury (DILI) in patients with existing liver disease. Methods: A retrospective cohort study was conducted, including adult tuberculosis patients with documented liver disease. Liver function was assessed using standard biochemical parameters, and FibroScan examinations were performed to determine liver stiffness measurement (LSM). Patients were monitored for clinical and biochemical signs of DILI throughout treatment. Logistic regression models and Receiver Operating Characteristic (ROC) curves were used for data analysis. Statistical significance was set at P<0.05. Results: Patients who developed DILI showed significantly higher levels of ALT, AST, total bilirubin, GGT, and LSM, with strong positive correlations between these markers and DILI occurrence. Logistic regression analysis revealed elevated ALT, AST, TBIL, and GGT were strongly associated with an increased likelihood of DILI. The area under the ROC curves indicated excellent predictive accuracy of these parameters. A nomogram for predicting DILI based on the combined biomarkers was established. Conclusions: The study demonstrates the feasibility of combining liver function indices and FibroScan measurements to predict anti-tuberculosis DILI. The results highlight the importance of baseline liver health assessment and offer promising implications for clinical practice, aiding in individualized risk estimation and therapeutic decision-making for patients with liver disease initiating anti-tuberculosis therapy. Further validation in larger cohorts is warranted to strengthen the predictive model.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501017S.pdfliver function indicesfibroscananti-tuberculosis drug-induced liver injuryliver diseasenomogram |
| spellingShingle | Shaoqiang Wu Qiaohua Yang Huai Li Yongzhong Li The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease Journal of Medical Biochemistry liver function indices fibroscan anti-tuberculosis drug-induced liver injury liver disease nomogram |
| title | The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease |
| title_full | The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease |
| title_fullStr | The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease |
| title_full_unstemmed | The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease |
| title_short | The feasibility of using liver function indices and FibroScan in combination to predict the occurrence of anti-tuberculosis drug-induced liver injury in Patients with liver disease |
| title_sort | feasibility of using liver function indices and fibroscan in combination to predict the occurrence of anti tuberculosis drug induced liver injury in patients with liver disease |
| topic | liver function indices fibroscan anti-tuberculosis drug-induced liver injury liver disease nomogram |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501017S.pdf |
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