HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients

HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients

ABSTRACT Objective: To study the genetic susceptibility to neuromyelitis optica (NMO) as well as the relationship between HLA genotypes and susceptibility to the disease in the southern Brazilian population. Methods: We analyzed patients with NMO, who met criteria for Wingerchuk's diagnosis o...

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Main Authors: Cláudia Suemi Kamoi Kay, Rosana Herminia Scola, Raquel Cristina Arndt, Paulo José Lorenzoni, Lineu Cesar Werneck
Format: Article
Language:English
Published: Thieme Revinter Publicações 2019-05-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
Genetic predisposition to disease
HLA antigens
immunogenetics
major histocompatibility complex
neuromyelitis optica
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000400239&lng=en&tlng=en
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Summary:ABSTRACT Objective: To study the genetic susceptibility to neuromyelitis optica (NMO) as well as the relationship between HLA genotypes and susceptibility to the disease in the southern Brazilian population. Methods: We analyzed patients with NMO, who met criteria for Wingerchuk's diagnosis of NMO, with detected serum anti-AQP4-IgG antibody. The HLA genotyping was performed by high-resolution techniques (Sanger sequencing) in patients and controls. The HLA genotypes were statistically compared with a paired control population. Results: The HLA genotyping revealed the diversity of the southern Brazilian population whose HLA profile resembled European and Asian populations. Some alleles had statistical correlations with a positive association (increased susceptibility) with NMO, particularly the HLA-DRB1*04:05 and *16:02. Conclusions: In our study, the HLA genotype was different to that previously reported for other Brazilian populations. Although our study had a small cohort, HLA genotypes were associated with increased susceptibility to NMO for HLA-DRB1*04:05 and *16:02. The alleles of HLA class I HLA-A*02:08 and *30:09, HLA-B*08:04 and *35:04 showed an association before the Bonferroni correction.
ISSN:1678-4227

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