Exploring the role of ubiquitination modifications in migraine headaches
Migraine is a complex neurovascular disorder whose pathogenesis involves activation of the trigeminal vascular system, central and peripheral sensitization, and neuroinflammation. Calcitonin gene-related peptide (CGRP) plays a dominant role and activation of MAPK and NF-κB signaling pathways regulat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534389/full |
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| author | Qian Zhu Qian Zhu Jin Yang Jin Yang Lei Shi Lei Shi Jieying Zhang Jieying Zhang Peng Zhang Peng Zhang Junlong Li Junlong Li Xiaoli Song Xiaoli Song |
| author_facet | Qian Zhu Qian Zhu Jin Yang Jin Yang Lei Shi Lei Shi Jieying Zhang Jieying Zhang Peng Zhang Peng Zhang Junlong Li Junlong Li Xiaoli Song Xiaoli Song |
| author_sort | Qian Zhu |
| collection | DOAJ |
| description | Migraine is a complex neurovascular disorder whose pathogenesis involves activation of the trigeminal vascular system, central and peripheral sensitization, and neuroinflammation. Calcitonin gene-related peptide (CGRP) plays a dominant role and activation of MAPK and NF-κB signaling pathways regulates neuropeptide release, glial cell activation, and amplification of nociceptive signals. Aberrant activation of these pathways drives migraine onset and chronicity. The ubiquitin-proteasome system (UPS) is involved in neurological and inflammatory disorders. ubiquitination in the UPS is achieved through a cascade of enzymes, including Ub-activating enzyme (E1), Ub-coupling enzyme (E2), and Ub-ligase (E3). The aim of this review is to systematically explore the role of ubiquitination in the regulation of MAPK and NF-κB signaling pathways, with a focus on the mechanisms of ubiquitinating enzymes in neuroinflammation and pain signal amplification, and to explore their potential as diagnostics, biomarkers, predictors of response to therapy, and monitoring of chronicity in migraine disease. |
| format | Article |
| id | doaj-art-f2c103e2e9a44ae2bbb7f13128cf5604 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-f2c103e2e9a44ae2bbb7f13128cf56042025-01-31T06:41:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15343891534389Exploring the role of ubiquitination modifications in migraine headachesQian Zhu0Qian Zhu1Jin Yang2Jin Yang3Lei Shi4Lei Shi5Jieying Zhang6Jieying Zhang7Peng Zhang8Peng Zhang9Junlong Li10Junlong Li11Xiaoli Song12Xiaoli Song13First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaMigraine is a complex neurovascular disorder whose pathogenesis involves activation of the trigeminal vascular system, central and peripheral sensitization, and neuroinflammation. Calcitonin gene-related peptide (CGRP) plays a dominant role and activation of MAPK and NF-κB signaling pathways regulates neuropeptide release, glial cell activation, and amplification of nociceptive signals. Aberrant activation of these pathways drives migraine onset and chronicity. The ubiquitin-proteasome system (UPS) is involved in neurological and inflammatory disorders. ubiquitination in the UPS is achieved through a cascade of enzymes, including Ub-activating enzyme (E1), Ub-coupling enzyme (E2), and Ub-ligase (E3). The aim of this review is to systematically explore the role of ubiquitination in the regulation of MAPK and NF-κB signaling pathways, with a focus on the mechanisms of ubiquitinating enzymes in neuroinflammation and pain signal amplification, and to explore their potential as diagnostics, biomarkers, predictors of response to therapy, and monitoring of chronicity in migraine disease.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534389/fullubiquitinationmigraineinflammationbiomarkercentral sensitizationperipheral sensitization |
| spellingShingle | Qian Zhu Qian Zhu Jin Yang Jin Yang Lei Shi Lei Shi Jieying Zhang Jieying Zhang Peng Zhang Peng Zhang Junlong Li Junlong Li Xiaoli Song Xiaoli Song Exploring the role of ubiquitination modifications in migraine headaches Frontiers in Immunology ubiquitination migraine inflammation biomarker central sensitization peripheral sensitization |
| title | Exploring the role of ubiquitination modifications in migraine headaches |
| title_full | Exploring the role of ubiquitination modifications in migraine headaches |
| title_fullStr | Exploring the role of ubiquitination modifications in migraine headaches |
| title_full_unstemmed | Exploring the role of ubiquitination modifications in migraine headaches |
| title_short | Exploring the role of ubiquitination modifications in migraine headaches |
| title_sort | exploring the role of ubiquitination modifications in migraine headaches |
| topic | ubiquitination migraine inflammation biomarker central sensitization peripheral sensitization |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534389/full |
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