Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation

Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation

The recent surge in therapeutic mRNA for vaccination has provided a blueprint for the design of the mRNA molecule, as several complex structural elements indicated as 5′ and 3′ untranslated regions (UTRs) and poly-A tail have been identified as necessary for in vitro transcribed mRNA stability and r...

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Bibliographic Details
Main Authors: Arthur Esprit, Dorien Autaers, Ilke Aernout, Ine Lentacker, Steve Pascolo, Kris Thielemans, Karine Breckpot, Lorenzo Franceschini
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
neoepitope
vaccination
cancer
lipid nanoparticles
IVT-mRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001453
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http://www.sciencedirect.com/science/article/pii/S2162253125001453

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