Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG
The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/809313 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549483081105408 |
|---|---|
| author | Behyar Zoghi Paul Shaughnessy Roger M. Lyons Richard Helmer Carlos Bachier C. Frederick LeMaistre |
| author_facet | Behyar Zoghi Paul Shaughnessy Roger M. Lyons Richard Helmer Carlos Bachier C. Frederick LeMaistre |
| author_sort | Behyar Zoghi |
| collection | DOAJ |
| description | The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous stem cell transplant (ASCT) are at significant risk of bleeding due to the profound thrombocytopenia, low Factor VIII levels, fever, and toxicities associated with the preparative regimen. We report a patient with AVWS associated with multiple myeloma who underwent autologous stem cell transplants as consolidation after initial induction and again at relapse. He was successfully treated with high dose intravenous immunoglobulin (IVIG) prior to each transplant with rapid resolution of AVWS. |
| format | Article |
| id | doaj-art-f27dbb54df5e4ded9e8b1af24f3bf423 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-f27dbb54df5e4ded9e8b1af24f3bf4232025-02-03T06:11:13ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/809313809313Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIGBehyar Zoghi0Paul Shaughnessy1Roger M. Lyons2Richard Helmer3Carlos Bachier4C. Frederick LeMaistre5Adult Blood and Marrow Transplant, Texas Transplant Institute, San Antonio, TX, USAAdult Blood and Marrow Transplant, Texas Transplant Institute, San Antonio, TX, USACancer Care Centers of South Texas, 4411 Medical Drive, San Antonio, TX, USATexas Oncology, 901 W. 38th Street, Suite 200, Austin, TX 78705, USAAdult Blood and Marrow Transplant, Texas Transplant Institute, San Antonio, TX, USASarah Cannon Blood Cancer Network, Nashville, TN 37203, USAThe use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous stem cell transplant (ASCT) are at significant risk of bleeding due to the profound thrombocytopenia, low Factor VIII levels, fever, and toxicities associated with the preparative regimen. We report a patient with AVWS associated with multiple myeloma who underwent autologous stem cell transplants as consolidation after initial induction and again at relapse. He was successfully treated with high dose intravenous immunoglobulin (IVIG) prior to each transplant with rapid resolution of AVWS.http://dx.doi.org/10.1155/2015/809313 |
| spellingShingle | Behyar Zoghi Paul Shaughnessy Roger M. Lyons Richard Helmer Carlos Bachier C. Frederick LeMaistre Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG Case Reports in Hematology |
| title | Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG |
| title_full | Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG |
| title_fullStr | Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG |
| title_full_unstemmed | Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG |
| title_short | Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG |
| title_sort | treatment of acquired von willebrand syndrome and prevention of bleeding postautologous stem cell transplant during severe pancytopenia with ivig |
| url | http://dx.doi.org/10.1155/2015/809313 |
| work_keys_str_mv | AT behyarzoghi treatmentofacquiredvonwillebrandsyndromeandpreventionofbleedingpostautologousstemcelltransplantduringseverepancytopeniawithivig AT paulshaughnessy treatmentofacquiredvonwillebrandsyndromeandpreventionofbleedingpostautologousstemcelltransplantduringseverepancytopeniawithivig AT rogermlyons treatmentofacquiredvonwillebrandsyndromeandpreventionofbleedingpostautologousstemcelltransplantduringseverepancytopeniawithivig AT richardhelmer treatmentofacquiredvonwillebrandsyndromeandpreventionofbleedingpostautologousstemcelltransplantduringseverepancytopeniawithivig AT carlosbachier treatmentofacquiredvonwillebrandsyndromeandpreventionofbleedingpostautologousstemcelltransplantduringseverepancytopeniawithivig AT cfredericklemaistre treatmentofacquiredvonwillebrandsyndromeandpreventionofbleedingpostautologousstemcelltransplantduringseverepancytopeniawithivig |