Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese

Abstract Background Non-small cell carcinoma is the main pathologic type of lung cancer, and a large number of clinical trials have shown that epidermal growth factor receptor tyrosinase inhibitors exhibit superior clinical efficacy and lower toxicity compared with chemotherapy. FHND9041 is a new ir...

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Main Authors: Chang Lu, Dongmei Cheng, Yunqiu Xie, Minghong Shang, Rongzhen Chen, Yongqiang Zhu, Jian Gong, Huan Zhou
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Online Access:https://doi.org/10.1186/s40360-025-00930-2
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