Efficacy and safety of intrapleural administration of sodium bicarbonate in patients with acute empyema and complicated parapneumonic effusion: protocol for a prospective, single-arm, interventional study

Efficacy and safety of intrapleural administration of sodium bicarbonate in patients with acute empyema and complicated parapneumonic effusion: protocol for a prospective, single-arm, interventional study

Abstract Background The standard treatment for acute empyema/complicated parapneumonic effusion (CPPE) is antibiotic administration and continuous chest drainage. However, adequate drainage becomes impossible in multichambered pleural effusion and some patients may require surgery or may die. In Jap...

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Main Authors: Yuichiro Suzukawa, Shuhei Teranishi, Sachi Takakura, Ryo Nakadegawa, Shunsuke Okazaki, Anna Tanaka, Shinya Matsushita, Tatsuya Muraoka, Tomofumi Hirose, Chihiro Maeda, Kenichi Seki, Ken Tashiro, Nobuaki Kobayashi, Masaki Yamamoto, Makoto Kudo, Takeshi Kaneko
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Infectious Diseases
Subjects:
Chest drainage
Complicated parapneumonic effusion
Empyema
Sodium bicarbonate
Urokinase
Online Access:https://doi.org/10.1186/s12879-025-11002-5
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https://doi.org/10.1186/s12879-025-11002-5

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