HDL attenuates Ang II–AT1R–EGFR signaling and reverses vascular remodeling in spontaneously hypertensive rats

HDL attenuates Ang II–AT1R–EGFR signaling and reverses vascular remodeling in spontaneously hypertensive rats

BackgroundAngiotensin II (Ang II) signaling via angiotensin II type 1 receptor (AT1R) and transactivation of epidermal growth factor receptor (EGFR) enhances vascular smooth muscle cell (VSMC) proliferation and contributes to vascular remodeling evident in spontaneously hypertensive rats (SHR) aorta...

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Bibliographic Details
Main Authors: Aishah Al-Jarallah, Samah Kalakh, Saghir Akhtar, Mariam H. M. Yousif
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
HDL
angiotensin II
SR-BI
vascular remodeling
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1617420/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1617420/full

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