scStateDynamics: deciphering the drug-responsive tumor cell state dynamics by modeling single-cell level expression changes

scStateDynamics: deciphering the drug-responsive tumor cell state dynamics by modeling single-cell level expression changes

Abstract Understanding tumor cell heterogeneity and plasticity is crucial for overcoming drug resistance. Single-cell technologies enable analyzing cell states at a given condition, but catenating static cell snapshots to characterize dynamic drug responses remains challenging. Here, we propose scSt...

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Bibliographic Details
Main Authors: Wenbo Guo, Xinqi Li, Dongfang Wang, Nan Yan, Qifan Hu, Fan Yang, Xuegong Zhang, Jianhua Yao, Jin Gu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Genome Biology
Subjects:
Single-cell
Dynamics
Tumor
Drug response
Online Access:https://doi.org/10.1186/s13059-024-03436-y
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https://doi.org/10.1186/s13059-024-03436-y

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