Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study
Abstract Objective: This study analyzed the practice of switching intravenous antibiotics to oral dosage form in a tertiary care hospital of Nepal. Design: A prospective observational study was performed among patients admitted to medical/surgical wards in a private tertiary care hospital of Nep...
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| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X24004947/type/journal_article |
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| author | Upasana Acharya Sweta Shrestha Aastha Rawal Laxmi Dangol Binaya Sapkota |
| author_facet | Upasana Acharya Sweta Shrestha Aastha Rawal Laxmi Dangol Binaya Sapkota |
| author_sort | Upasana Acharya |
| collection | DOAJ |
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Abstract
Objective:
This study analyzed the practice of switching intravenous antibiotics to oral dosage form in a tertiary care hospital of Nepal.
Design:
A prospective observational study was performed among patients admitted to medical/surgical wards in a private tertiary care hospital of Nepal.
Methods:
Hospitalized adult patients who received IV antibiotics for at least 48 hours and met the eligibility criteria were enrolled in the study. The detailed information on use of antibiotics such as indication, duration, type time of switch etc. were collected and analyzed.
Results:
Among 335 patients, 282(83.9%) met the eligibility criteria for intravenous (IV) to oral conversion however, only 18.7% of patients were switched to oral regimen. Step-down conversion was the common type of IV to oral switch. Almost all patients were empirically treated with β-lactams antibiotics (n = 327). There was significant association between the antibiotic class and duration of IV therapy (P < 0.001). The length of hospital stays and duration of IV antibiotics therapy was lower in the timely converted group than in the non-converted groups (P < 0.001). The duration of IV antibiotics therapy was strongly correlated with duration of hospital stay (r = 0.743, P < 0.001).
Conclusion:
The findings revealed a low prevalence of conversion from IV antibiotics to oral, despite a higher percentage of patients meeting the eligibility criteria for conversion. There is a need for the implementation of structured program to review patients on IV antibiotics and promote timely conversion to oral once they meet the conversion criteria.
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| format | Article |
| id | doaj-art-f22e010b3564428b88bc51fe9f9bdcc7 |
| institution | Kabale University |
| issn | 2732-494X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj-art-f22e010b3564428b88bc51fe9f9bdcc72025-01-27T10:12:23ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2025-01-01510.1017/ash.2024.494Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational studyUpasana Acharya0https://orcid.org/0000-0002-0475-661XSweta Shrestha1https://orcid.org/0000-0001-8651-2645Aastha Rawal2Laxmi Dangol3Binaya Sapkota4https://orcid.org/0000-0002-4125-9866Department of Critical Care Medicine, Grande International Hospital, Tokha, Kathmandu, NepalDepartment of Pharmacy, Kathmandu University, Dhulikhel, Kavre, NepalDepartment of Infection Control, Manmohan Memorial Medical College and Teaching Hospital, Swoyambhu, Kathmandu, NepalDepartment of Infection Prevention and Control, Grande International Hospital, Tokha, Kathmandu, NepalDepartment of Pharmaceutical Sciences, Nobel College Faculty of Health Sciences, Sinamangal, Kathmandu, Nepal Abstract Objective: This study analyzed the practice of switching intravenous antibiotics to oral dosage form in a tertiary care hospital of Nepal. Design: A prospective observational study was performed among patients admitted to medical/surgical wards in a private tertiary care hospital of Nepal. Methods: Hospitalized adult patients who received IV antibiotics for at least 48 hours and met the eligibility criteria were enrolled in the study. The detailed information on use of antibiotics such as indication, duration, type time of switch etc. were collected and analyzed. Results: Among 335 patients, 282(83.9%) met the eligibility criteria for intravenous (IV) to oral conversion however, only 18.7% of patients were switched to oral regimen. Step-down conversion was the common type of IV to oral switch. Almost all patients were empirically treated with β-lactams antibiotics (n = 327). There was significant association between the antibiotic class and duration of IV therapy (P < 0.001). The length of hospital stays and duration of IV antibiotics therapy was lower in the timely converted group than in the non-converted groups (P < 0.001). The duration of IV antibiotics therapy was strongly correlated with duration of hospital stay (r = 0.743, P < 0.001). Conclusion: The findings revealed a low prevalence of conversion from IV antibiotics to oral, despite a higher percentage of patients meeting the eligibility criteria for conversion. There is a need for the implementation of structured program to review patients on IV antibiotics and promote timely conversion to oral once they meet the conversion criteria. https://www.cambridge.org/core/product/identifier/S2732494X24004947/type/journal_article |
| spellingShingle | Upasana Acharya Sweta Shrestha Aastha Rawal Laxmi Dangol Binaya Sapkota Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study Antimicrobial Stewardship & Healthcare Epidemiology |
| title | Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study |
| title_full | Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study |
| title_fullStr | Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study |
| title_full_unstemmed | Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study |
| title_short | Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study |
| title_sort | analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in nepal a prospective observational study |
| url | https://www.cambridge.org/core/product/identifier/S2732494X24004947/type/journal_article |
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