Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels
BackgroundVitamins are essential micronutrients for the prevention and treatment of neurodegenerative diseases. The objectives of the present study were to evaluate the association between dietary vitamin intake and cognitive function in elderly adults and to explore the potential impact of serum ne...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1485648/full |
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| author | Zhikui Zhou Baiyun Fan Qiang Chen Xuezhong Li Xianjin Ke |
| author_facet | Zhikui Zhou Baiyun Fan Qiang Chen Xuezhong Li Xianjin Ke |
| author_sort | Zhikui Zhou |
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| description | BackgroundVitamins are essential micronutrients for the prevention and treatment of neurodegenerative diseases. The objectives of the present study were to evaluate the association between dietary vitamin intake and cognitive function in elderly adults and to explore the potential impact of serum neurofilament light chain (NfL) concentration.MethodsData from 468 elderly individuals, including information on the dietary consumption of 10 vitamins, were used. Cognitive performance was assessed according to a composite Z-score of the Animal Fluency Test (AFT), Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), and Digit Symbol Substitution Test (DSST). Serum NfL levels were measured using a highly sensitive immunoassay. Bayesian kernel machine regression (BKMR) models were used to estimate the combined effects of vitamin mixtures on cognitive function.ResultsIn both single- and multiple-vitamin models, individuals with a higher intake of dietary vitamin K exhibited greater global cognitive function, compared to those with a lower vitamin intake. BKMR revealed positive associations between vitamin mixtures and global cognitive function, AFT Z-scores, and DSST Z-scores. Individuals in the third vitamin K intake tertile exhibited lower serum NfL levels than those in the first tertile (regression coefficient, β = −0.16 [95% confidence interval −0.29 to −0.02]; p = 0.023). Serum NfL levels mediated the association between higher vitamin K intake and global cognitive function (8.73%).ConclusionVitamin mixtures were positively associated with global cognitive function in elderly participants. The association between vitamin K intake and cognitive function may be mediated by serum NfL concentration. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-f21e49f116c348df98bde6029dfecea32025-01-29T05:21:22ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.14856481485648Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levelsZhikui Zhou0Baiyun Fan1Qiang Chen2Xuezhong Li3Xianjin Ke4Department of Neurology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Neurology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Neurology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Neurology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaBackgroundVitamins are essential micronutrients for the prevention and treatment of neurodegenerative diseases. The objectives of the present study were to evaluate the association between dietary vitamin intake and cognitive function in elderly adults and to explore the potential impact of serum neurofilament light chain (NfL) concentration.MethodsData from 468 elderly individuals, including information on the dietary consumption of 10 vitamins, were used. Cognitive performance was assessed according to a composite Z-score of the Animal Fluency Test (AFT), Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), and Digit Symbol Substitution Test (DSST). Serum NfL levels were measured using a highly sensitive immunoassay. Bayesian kernel machine regression (BKMR) models were used to estimate the combined effects of vitamin mixtures on cognitive function.ResultsIn both single- and multiple-vitamin models, individuals with a higher intake of dietary vitamin K exhibited greater global cognitive function, compared to those with a lower vitamin intake. BKMR revealed positive associations between vitamin mixtures and global cognitive function, AFT Z-scores, and DSST Z-scores. Individuals in the third vitamin K intake tertile exhibited lower serum NfL levels than those in the first tertile (regression coefficient, β = −0.16 [95% confidence interval −0.29 to −0.02]; p = 0.023). Serum NfL levels mediated the association between higher vitamin K intake and global cognitive function (8.73%).ConclusionVitamin mixtures were positively associated with global cognitive function in elderly participants. The association between vitamin K intake and cognitive function may be mediated by serum NfL concentration.https://www.frontiersin.org/articles/10.3389/fnut.2025.1485648/fullcognitive functionBayesian kernel machine regressionvitaminsvitamin Kneurofilament light chain |
| spellingShingle | Zhikui Zhou Baiyun Fan Qiang Chen Xuezhong Li Xianjin Ke Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels Frontiers in Nutrition cognitive function Bayesian kernel machine regression vitamins vitamin K neurofilament light chain |
| title | Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels |
| title_full | Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels |
| title_fullStr | Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels |
| title_full_unstemmed | Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels |
| title_short | Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels |
| title_sort | individual and combined effects of dietary vitamin intake on cognitive function in elderly adults the potential mediating role of serum neurofilament light chain levels |
| topic | cognitive function Bayesian kernel machine regression vitamins vitamin K neurofilament light chain |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1485648/full |
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