Pharmacologic properties and inhibitory activity of 6-azasteroids against Mycobacterium leprae in vivo and in vitro

Pharmacologic properties and inhibitory activity of 6-azasteroids against Mycobacterium leprae in vivo and in vitro

ABSTRACT Although the current multidrug therapy (MDT) for leprosy is very successful, the long treatment duration and the emergence of antibiotic-resistant strains demand for new alternative drugs. One potential target for drug development against pathogenic mycobacteria is their need to degrade hos...

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Main Authors: Thabatta L. S. A. Rosa, Maria Angela M. Marques, Tianao Yuan, Daniele F. F. Bertoluci, Joshua Werman, Fabricio da M. R. Costa, Linda A. Fischbacher, Mariana de Andrea Hacker, Ramanuj Lahiri, Márcia Bêrredo-Pinho, Patrícia S. Rosa, John T. Belisle, Nicole S. Sampson, Maria Cristina V. Pessolani
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium leprae
cholesterol
cholestenone
3β-HSD
6-azasteroids
chemotherapy
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00228-25
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https://journals.asm.org/doi/10.1128/spectrum.00228-25

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