BAFF and APRIL immunotherapy following Bacille Calmette-Guérin vaccination enhances protection against pulmonary tuberculosis in mice

BAFF and APRIL immunotherapy following Bacille Calmette-Guérin vaccination enhances protection against pulmonary tuberculosis in mice

IntroductionBacille Calmette-Guérin (BCG), the only tuberculosis vaccine currently in clinical use, provides inadequate long-term protection. Administered at birth, BCG induces broad immune responses against a large number of antigens shared with Mycobacterium tuberculosis (Mtb), but protection wane...

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Bibliographic Details
Main Authors: Min Xie, Chen-Yu Tsai, Joshua Woo, Frank Nuritdinov, Melissa Cristaldo, Narineh M. Odjourian, Rosleine Antilus-Sainte, Maureen Dougher, Martin Gengenbacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
BCG
unconventional B cells
marginal-zone B cells
immunotherapy
memory T cells
mycobacterium tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551183/full
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