Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits
In this experimental study we have investigated whether the inclusion of the dietary fiber Plantago ovata husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of Plantago ovata husk-metformin association in diabetic rabbits by determining its effe...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/167526 |
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| author | Raquel Díez-Láiz Juan J. García-Vieitez M. José Diez-Liébana Matilde Sierra-Vega Ana M. Sahagún-Prieto Ángela P. Calle-Pardo Nélida Fernández-Martínez |
| author_facet | Raquel Díez-Láiz Juan J. García-Vieitez M. José Diez-Liébana Matilde Sierra-Vega Ana M. Sahagún-Prieto Ángela P. Calle-Pardo Nélida Fernández-Martínez |
| author_sort | Raquel Díez-Láiz |
| collection | DOAJ |
| description | In this experimental study we have investigated whether the inclusion of the dietary fiber Plantago ovata husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of Plantago ovata husk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences in Cmax and tmax in relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in Cmax, AUC, and tmax in animals fed with fiber. We conclude that Plantago ovata husk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes. |
| format | Article |
| id | doaj-art-f17c06fd900f402e8ff6182e7c1a594a |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-f17c06fd900f402e8ff6182e7c1a594a2025-02-03T06:15:13ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/167526167526Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic RabbitsRaquel Díez-Láiz0Juan J. García-Vieitez1M. José Diez-Liébana2Matilde Sierra-Vega3Ana M. Sahagún-Prieto4Ángela P. Calle-Pardo5Nélida Fernández-Martínez6Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, SpainPharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, SpainPharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, SpainPharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, SpainPharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, SpainPharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, SpainPharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, SpainIn this experimental study we have investigated whether the inclusion of the dietary fiber Plantago ovata husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of Plantago ovata husk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences in Cmax and tmax in relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in Cmax, AUC, and tmax in animals fed with fiber. We conclude that Plantago ovata husk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes.http://dx.doi.org/10.1155/2015/167526 |
| spellingShingle | Raquel Díez-Láiz Juan J. García-Vieitez M. José Diez-Liébana Matilde Sierra-Vega Ana M. Sahagún-Prieto Ángela P. Calle-Pardo Nélida Fernández-Martínez Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits Journal of Diabetes Research |
| title | Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits |
| title_full | Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits |
| title_fullStr | Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits |
| title_full_unstemmed | Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits |
| title_short | Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits |
| title_sort | evaluation of the association metformin plantago ovata husk in diabetic rabbits |
| url | http://dx.doi.org/10.1155/2015/167526 |
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