Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN.

Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN.

Virus-derived double-stranded RNAs (dsRNAs) are sensed in the cytosol by retinoic acid-inducible gene (RIG)-I-like receptors (RLRs). These induce the expression of type I IFN and proinflammatory cytokines through signaling pathways mediated by the mitochondrial antiviral signaling (MAVS) protein. TN...

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Main Authors: Taishin Akiyama, Takuma Shiraishi, Junwen Qin, Hiroyasu Konno, Nobuko Akiyama, Miho Shinzawa, Maki Miyauchi, Nobukazu Takizawa, Hiromi Yanai, Hiroyuki Ohashi, Etsuko Miyamoto-Sato, Hiroshi Yanagawa, Weidong Yong, Weinian Shou, Jun-Ichiro Inoue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095992&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095992&type=printable

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