Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study
Objective To assess changes in metabolic risk factors and cancer-related growth factors associated with short-term abstinence from alcohol.Design Prospective, observational study.Setting Single tertiary centre.Participants Healthy subjects were recruited based on intention to: (1) abstain from alcoh...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2018-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/8/5/e020673.full |
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| author | Gautam Mehta Rajiv Jalan Matteo Rosselli James Maurice Stewart Macdonald Alexandra Cronberg Tanya Khera-Butler Colin Sumpter Safa Al-Khatib Anjly Jain Christos Charalambous Amir Gander Cynthia Ju Talay Hakan Roy Sherwood Devaki Nair Kevin P Moore |
| author_facet | Gautam Mehta Rajiv Jalan Matteo Rosselli James Maurice Stewart Macdonald Alexandra Cronberg Tanya Khera-Butler Colin Sumpter Safa Al-Khatib Anjly Jain Christos Charalambous Amir Gander Cynthia Ju Talay Hakan Roy Sherwood Devaki Nair Kevin P Moore |
| author_sort | Gautam Mehta |
| collection | DOAJ |
| description | Objective To assess changes in metabolic risk factors and cancer-related growth factors associated with short-term abstinence from alcohol.Design Prospective, observational study.Setting Single tertiary centre.Participants Healthy subjects were recruited based on intention to: (1) abstain from alcohol for 1 month (abstinence group), or (2) continue to drink alcohol (control group). Inclusion criteria were baseline alcohol consumption >64 g/week (men) or >48 g/week (women). Exclusion criteria were known liver disease or alcohol dependence.Primary and secondary outcome measures The primary outcome was change in insulin resistance (homeostatic model assessment (HOMA) score). Secondary outcomes were changes in weight, blood pressure (BP), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and liver function tests. Primary and secondary outcomes were adjusted for changes in diet, exercise and cigarette smoking.Results The abstinence group comprised 94 participants (mean age 45.5 years, SD ±1.2) and the control group 47 participants (mean age 48.7 years, SD ±1.8). Baseline alcohol consumption in the abstinence group was 258.2 g/week, SD ±9.4, and in the control group 233.8 g, SD ±19.0. Significant reductions from baseline in the abstinence group (all p<0.001) were found in: HOMA score (−25.9%, IQR −48.6% to +0.3%), systolic BP (−6.6%, IQR −11.8% to 0.0%), diastolic BP (−6.3%, IQR −14.1% to +1.3%), weight (−1.5%, IQR −2.9% to −0.4%), VEGF (−41.8%, IQR −64.9% to −17.9%) and EGF (−73.9%, IQR −86.1% to −36.4%). None of these changes were associated with changes in diet, exercise or cigarette smoking. No significant changes from baseline in primary or secondary outcomes were noted in the control group.Conclusion These findings demonstrate that abstinence from alcohol in moderate–heavy drinkers improves insulin resistance, weight, BP and cancer-related growth factors. These data support an independent association of alcohol consumption with cancer risk, and suggest an increased risk of metabolic diseases such as type 2 diabetes and fatty liver disease. |
| format | Article |
| id | doaj-art-f15b5268135f4e1db2ca7599e15c31a6 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2018-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-f15b5268135f4e1db2ca7599e15c31a62025-02-01T21:55:09ZengBMJ Publishing GroupBMJ Open2044-60552018-05-018510.1136/bmjopen-2017-020673Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational studyGautam Mehta0Rajiv Jalan1Matteo Rosselli2James Maurice3Stewart Macdonald4Alexandra Cronberg5Tanya Khera-Butler6Colin Sumpter7Safa Al-Khatib8Anjly Jain9Christos Charalambous10Amir Gander11Cynthia Ju12Talay Hakan13Roy Sherwood14Devaki Nair15Kevin P Moore1610 Liver Failure Group, Institute for Liver Disease Health, University College London, London, UK10 Liver Failure Group, Institute for Liver Disease Health, University College London, London, UK2 University College London, Royal Free Hospital, London, UK1 Division of Medicine, UCL Institute for Liver and Digestive Health, London, UK1 Division of Medicine, UCL Institute for Liver and Digestive Health, London, UK2 Camden and Islington Public Health, London, UK2 Camden and Islington Public Health, London, UKDepartment of Public Health, NHS Forth Valley, Stirling, UK1 Division of Medicine, UCL Institute for Liver and Digestive Health, London, UK3 Department of Clinical Biochemistry, Royal Free London NHS Foundation Trust, London, London, UK1 Division of Medicine, UCL Institute for Liver and Digestive Health, London, UKTissue Access for Patient Benefit, University College London, London, UKDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA6 Department of Liver Transplantation, HPB and Hepatology, Royal Free London NHS Foundation Trust, London, UK7 Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, London, UK8 Department of Clinical Biochemistry, Royal Free London NHS Foundation Trust, London, UK1 Division of Medicine, UCL Institute for Liver and Digestive Health, London, UKObjective To assess changes in metabolic risk factors and cancer-related growth factors associated with short-term abstinence from alcohol.Design Prospective, observational study.Setting Single tertiary centre.Participants Healthy subjects were recruited based on intention to: (1) abstain from alcohol for 1 month (abstinence group), or (2) continue to drink alcohol (control group). Inclusion criteria were baseline alcohol consumption >64 g/week (men) or >48 g/week (women). Exclusion criteria were known liver disease or alcohol dependence.Primary and secondary outcome measures The primary outcome was change in insulin resistance (homeostatic model assessment (HOMA) score). Secondary outcomes were changes in weight, blood pressure (BP), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and liver function tests. Primary and secondary outcomes were adjusted for changes in diet, exercise and cigarette smoking.Results The abstinence group comprised 94 participants (mean age 45.5 years, SD ±1.2) and the control group 47 participants (mean age 48.7 years, SD ±1.8). Baseline alcohol consumption in the abstinence group was 258.2 g/week, SD ±9.4, and in the control group 233.8 g, SD ±19.0. Significant reductions from baseline in the abstinence group (all p<0.001) were found in: HOMA score (−25.9%, IQR −48.6% to +0.3%), systolic BP (−6.6%, IQR −11.8% to 0.0%), diastolic BP (−6.3%, IQR −14.1% to +1.3%), weight (−1.5%, IQR −2.9% to −0.4%), VEGF (−41.8%, IQR −64.9% to −17.9%) and EGF (−73.9%, IQR −86.1% to −36.4%). None of these changes were associated with changes in diet, exercise or cigarette smoking. No significant changes from baseline in primary or secondary outcomes were noted in the control group.Conclusion These findings demonstrate that abstinence from alcohol in moderate–heavy drinkers improves insulin resistance, weight, BP and cancer-related growth factors. These data support an independent association of alcohol consumption with cancer risk, and suggest an increased risk of metabolic diseases such as type 2 diabetes and fatty liver disease.https://bmjopen.bmj.com/content/8/5/e020673.full |
| spellingShingle | Gautam Mehta Rajiv Jalan Matteo Rosselli James Maurice Stewart Macdonald Alexandra Cronberg Tanya Khera-Butler Colin Sumpter Safa Al-Khatib Anjly Jain Christos Charalambous Amir Gander Cynthia Ju Talay Hakan Roy Sherwood Devaki Nair Kevin P Moore Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study BMJ Open |
| title | Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study |
| title_full | Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study |
| title_fullStr | Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study |
| title_full_unstemmed | Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study |
| title_short | Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study |
| title_sort | short term abstinence from alcohol and changes in cardiovascular risk factors liver function tests and cancer related growth factors a prospective observational study |
| url | https://bmjopen.bmj.com/content/8/5/e020673.full |
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