Predominant T-cell epitopes of SARS-CoV-2 restricted by multiple prevalent HLA-B and HLA-C allotypes in Northeast Asia

Predominant T-cell epitopes of SARS-CoV-2 restricted by multiple prevalent HLA-B and HLA-C allotypes in Northeast Asia

Since the outbreak of novel coronavirus pneumonia (COVID-19), numerous T-cell epitopes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteome have been reported. However, most of the identified CD8+ T-cell epitopes have been restricted primarily by HLA-A allotypes. The epitopes res...

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Bibliographic Details
Main Authors: Yu Zhao, Min Peng, Chengtao He, Min Li, Xuelian Han, Qiang Fu, Yandan Wu, Fangping Yue, Chunguang Yan, Guangyu Zhao, Chuanlai Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
HLA-B allotype
HLA-C allotype
T-cell epitope
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1545510/full
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