Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

Sterol transport proteins (STPs) play a pivotal role in cholesterol homeostasis and therefore are essential for healthy human physiology. Despite recent advances in dissecting functions of STPs in the human cell, there is still a significant knowledge gap regarding their specific biological function...

Full description

Saved in:
Bibliographic Details
Main Authors: Laura Depta, Hogan P. Bryce-Rogers, Nienke J. Dekker, Anna Wiehl Bønke, Nicolò Camporese, Mingxing Qian, Yuanjian Xu, Douglas F. Covey, Luca Laraia
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Lipid Research
Subjects:
sterol transport proteins
ligand selectivity
small molecules
natural products
structure activity relationship
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524002438
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0022227524002438

Similar Items