Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas
The aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method. We developed a control al...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/245152 |
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| author | Nils K. Skjaervold Dan Östling Dag R. Hjelme Olav Spigset Oddveig Lyng Petter Aadahl |
| author_facet | Nils K. Skjaervold Dan Östling Dag R. Hjelme Olav Spigset Oddveig Lyng Petter Aadahl |
| author_sort | Nils K. Skjaervold |
| collection | DOAJ |
| description | The aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method. We developed a control algorithm based on repetitive intravenous bolus injections of insulin and combined this with an intravascular blood glucose monitor. Four anesthetized pigs were used in the study. The animals developed a mildly diabetic state from streptozotocin pretreatment. They were steadily brought within the blood glucose target range of 4.5–6.0 mmol/L in 21 to 121 min and kept within that range for 128 to 238 min (hypoglycemic values varied from 2.9 to 51.1 min). The study confirmed our hypotheses regarding the feasibility of this new principle for blood glucose control, and the algorithm was constantly improved during the study to produce the best results in the last animals. The main obstacles were the drift of the IvS-1 sensor and problems with the calibration procedure, which calls for an improvement in the sensor stability before this method can be applied fully in new studies in animals and humans. |
| format | Article |
| id | doaj-art-f13e7cdd204c42b0840d4d00411f8c7a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f13e7cdd204c42b0840d4d00411f8c7a2025-02-03T05:57:40ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/245152245152Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial PancreasNils K. Skjaervold0Dan Östling1Dag R. Hjelme2Olav Spigset3Oddveig Lyng4Petter Aadahl5Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, MTFS, Postbox 8905, 7491 Trondheim, NorwayInvivosense Norway Ltd., c/o NTNU Technology Transfer, Sem Saelands Vei 14, 7034 Trondheim, NorwayInvivosense Norway Ltd., c/o NTNU Technology Transfer, Sem Saelands Vei 14, 7034 Trondheim, NorwayDepartment of Laboratory Medicine, Children’s and Women’s Health, Norwegian University of Science and Technology, 7491 Trondheim, NorwayUnit of Comparative Medicine, Norwegian University of Science and Technology, 7491 Trondheim, NorwayDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, MTFS, Postbox 8905, 7491 Trondheim, NorwayThe aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method. We developed a control algorithm based on repetitive intravenous bolus injections of insulin and combined this with an intravascular blood glucose monitor. Four anesthetized pigs were used in the study. The animals developed a mildly diabetic state from streptozotocin pretreatment. They were steadily brought within the blood glucose target range of 4.5–6.0 mmol/L in 21 to 121 min and kept within that range for 128 to 238 min (hypoglycemic values varied from 2.9 to 51.1 min). The study confirmed our hypotheses regarding the feasibility of this new principle for blood glucose control, and the algorithm was constantly improved during the study to produce the best results in the last animals. The main obstacles were the drift of the IvS-1 sensor and problems with the calibration procedure, which calls for an improvement in the sensor stability before this method can be applied fully in new studies in animals and humans.http://dx.doi.org/10.1155/2013/245152 |
| spellingShingle | Nils K. Skjaervold Dan Östling Dag R. Hjelme Olav Spigset Oddveig Lyng Petter Aadahl Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas International Journal of Endocrinology |
| title | Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas |
| title_full | Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas |
| title_fullStr | Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas |
| title_full_unstemmed | Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas |
| title_short | Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas |
| title_sort | blood glucose control using a novel continuous blood glucose monitor and repetitive intravenous insulin boluses exploiting natural insulin pulsatility as a principle for a future artificial pancreas |
| url | http://dx.doi.org/10.1155/2013/245152 |
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