UBR-1 deficiency leads to ivermectin resistance in Caenorhabditis elegans

UBR-1 deficiency leads to ivermectin resistance in Caenorhabditis elegans

Resistance to anthelmintics, particularly the macrocyclic lactone ivermectin (IVM), presents a substantial global challenge for parasite control. We found that the functional loss of an evolutionarily conserved E3 ubiquitin ligase, UBR-1, leads to IVM resistance in Caenorhabditis elegans. Multiple I...

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Bibliographic Details
Main Authors: Yi Li, Long Gong, Jing Wu, Wesley Hung, Mei Zhen, Shangbang Gao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
Anthelmintic resistance
Ivermectin
UBR-1 deficiency
glutamate metabolism
GluCls
Ceftriaxone
Online Access:https://elifesciences.org/articles/103718
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