Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of Sarcoidosis
Although hypercalcemia is a known metabolic complication of sarcoidosis, it is rarely a presenting manifestation. Long-standing hypercalcemia and hypercalciuria can cause nephrocalcinosis and chronic renal failure. Acute renal failure, although described, is also a rare presentation of patients with...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/423659 |
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| author | Rudruidee Karnchanasorn Molly Sarikonda Saleh Aldasouqi Ved V. Gossain |
| author_facet | Rudruidee Karnchanasorn Molly Sarikonda Saleh Aldasouqi Ved V. Gossain |
| author_sort | Rudruidee Karnchanasorn |
| collection | DOAJ |
| description | Although hypercalcemia is a known metabolic complication of sarcoidosis, it is rarely a presenting manifestation. Long-standing hypercalcemia and hypercalciuria can cause nephrocalcinosis and chronic renal failure. Acute renal failure, although described, is also a rare presentation of patients with sarcoidosis. We describe two patients with sarcoidosis, who presented with severe hypercalcemia and worsening renal function. Parathyroid hormone levels were appropriately suppressed. This led to an extensive search for the cause of hypercalcemia. Finally, after a lymph node biopsy in both cases, a diagnosis of sarcoidosis was established, hypercalcemia resolved, and renal function improved in both cases after administration of prednisone. |
| format | Article |
| id | doaj-art-f129f1a5d899404f8eaf40bdeb76e0d1 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-f129f1a5d899404f8eaf40bdeb76e0d12025-02-03T06:13:32ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/423659423659Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of SarcoidosisRudruidee Karnchanasorn0Molly Sarikonda1Saleh Aldasouqi2Ved V. Gossain3Department of Diabetes, Endocrinology & Metabolism, City of Hope, University of California, 1500 East Duarte Road, Duarte, CA 91010, USADepartment of Internal Medicine - Infectious Diseases, Washington University, Campus Box 8051, St. Louis, MO 63130, USAMichigan State University, East Lansing, MI 48824, USAMichigan State University, East Lansing, MI 48824, USAAlthough hypercalcemia is a known metabolic complication of sarcoidosis, it is rarely a presenting manifestation. Long-standing hypercalcemia and hypercalciuria can cause nephrocalcinosis and chronic renal failure. Acute renal failure, although described, is also a rare presentation of patients with sarcoidosis. We describe two patients with sarcoidosis, who presented with severe hypercalcemia and worsening renal function. Parathyroid hormone levels were appropriately suppressed. This led to an extensive search for the cause of hypercalcemia. Finally, after a lymph node biopsy in both cases, a diagnosis of sarcoidosis was established, hypercalcemia resolved, and renal function improved in both cases after administration of prednisone.http://dx.doi.org/10.1155/2010/423659 |
| spellingShingle | Rudruidee Karnchanasorn Molly Sarikonda Saleh Aldasouqi Ved V. Gossain Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of Sarcoidosis Case Reports in Medicine |
| title | Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of Sarcoidosis |
| title_full | Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of Sarcoidosis |
| title_fullStr | Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of Sarcoidosis |
| title_full_unstemmed | Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of Sarcoidosis |
| title_short | Severe Hypercalcemia and Acute Renal Failure: An Unusual Presentation of Sarcoidosis |
| title_sort | severe hypercalcemia and acute renal failure an unusual presentation of sarcoidosis |
| url | http://dx.doi.org/10.1155/2010/423659 |
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