Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications
In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the o...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/751793 |
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| author | Alessia Alunno Mirko Manetti Sara Caterbi Lidia Ibba-Manneschi Onelia Bistoni Elena Bartoloni Valentina Valentini Riccardo Terenzi Roberto Gerli |
| author_facet | Alessia Alunno Mirko Manetti Sara Caterbi Lidia Ibba-Manneschi Onelia Bistoni Elena Bartoloni Valentina Valentini Riccardo Terenzi Roberto Gerli |
| author_sort | Alessia Alunno |
| collection | DOAJ |
| description | In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the other hand, regulatory T (Treg) cells are a T cell subset whose peculiar function is to suppress autoreactive lymphocytes. The imbalance between Th17 and Treg cells has been identified as a crucial event in the pathogenesis of RA. In addition, the effects of currently employed RA therapeutic strategies on these lymphocyte subpopulations have been extensively investigated. This review article aims to discuss current knowledge on Treg and Th17 cells in RA and possible implications of their therapeutic targeting in this disorder. |
| format | Article |
| id | doaj-art-f12792cc27db4ff9b89d7c4c0d11c8c3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f12792cc27db4ff9b89d7c4c0d11c8c32025-02-03T05:50:21ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/751793751793Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic ImplicationsAlessia Alunno0Mirko Manetti1Sara Caterbi2Lidia Ibba-Manneschi3Onelia Bistoni4Elena Bartoloni5Valentina Valentini6Riccardo Terenzi7Roberto Gerli8Rheumatology Unit, Department of Medicine, University of Perugia, 06132 Perugia, ItalyDepartment of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, 50134 Florence, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06132 Perugia, ItalyDepartment of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, 50134 Florence, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06132 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06132 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06132 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06132 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06132 Perugia, ItalyIn recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the other hand, regulatory T (Treg) cells are a T cell subset whose peculiar function is to suppress autoreactive lymphocytes. The imbalance between Th17 and Treg cells has been identified as a crucial event in the pathogenesis of RA. In addition, the effects of currently employed RA therapeutic strategies on these lymphocyte subpopulations have been extensively investigated. This review article aims to discuss current knowledge on Treg and Th17 cells in RA and possible implications of their therapeutic targeting in this disorder.http://dx.doi.org/10.1155/2015/751793 |
| spellingShingle | Alessia Alunno Mirko Manetti Sara Caterbi Lidia Ibba-Manneschi Onelia Bistoni Elena Bartoloni Valentina Valentini Riccardo Terenzi Roberto Gerli Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications Mediators of Inflammation |
| title | Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications |
| title_full | Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications |
| title_fullStr | Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications |
| title_full_unstemmed | Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications |
| title_short | Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications |
| title_sort | altered immunoregulation in rheumatoid arthritis the role of regulatory t cells and proinflammatory th17 cells and therapeutic implications |
| url | http://dx.doi.org/10.1155/2015/751793 |
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