Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects
It is now well established that not all obese subjects are at increased risk of cardiometabolic complications; such patients are termed the metabolically healthy obese. Despite their higher-than-normal body fat mass, they are still insulin sensitive, with a favorable inflammatory and lipid profile a...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/170434 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548743991263232 |
|---|---|
| author | Assim A. Alfadda |
| author_facet | Assim A. Alfadda |
| author_sort | Assim A. Alfadda |
| collection | DOAJ |
| description | It is now well established that not all obese subjects are at increased risk of cardiometabolic complications; such patients are termed the metabolically healthy obese. Despite their higher-than-normal body fat mass, they are still insulin sensitive, with a favorable inflammatory and lipid profile and no signs of hypertension. It remains unclear which factors determine an individual's metabolic health. Adipose tissue is known to secrete multiple bioactive substances, called adipokines, that can contribute to the development of obesity-associated complications. The goal of this study was to determine whether the circulating adipokine profiles differs between metabolically healthy and metabolically unhealthy overweight and obese subjects, thereby obtaining data that could help to explain the link between obesity and its related cardiometabolic complications. We defined metabolic health in terms of several metabolic and inflammatory risk factors. The serum adiponectin levels were higher in the healthy group and showed a positive correlation with HDL cholesterol levels in the unhealthy group. There were no differences between the two groups in the levels of serum leptin, chemerin and orosomucoid. Accordingly, adiponectin might play a role in protecting against obesity-associated cardiometabolic derangements. More studies are needed to clarify the role of different chemerin isoforms in this system. |
| format | Article |
| id | doaj-art-f0f491a59e824c14ba9ac2dcdd809777 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f0f491a59e824c14ba9ac2dcdd8097772025-02-03T06:13:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/170434170434Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese SubjectsAssim A. Alfadda0Obesity Research Center and the Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi ArabiaIt is now well established that not all obese subjects are at increased risk of cardiometabolic complications; such patients are termed the metabolically healthy obese. Despite their higher-than-normal body fat mass, they are still insulin sensitive, with a favorable inflammatory and lipid profile and no signs of hypertension. It remains unclear which factors determine an individual's metabolic health. Adipose tissue is known to secrete multiple bioactive substances, called adipokines, that can contribute to the development of obesity-associated complications. The goal of this study was to determine whether the circulating adipokine profiles differs between metabolically healthy and metabolically unhealthy overweight and obese subjects, thereby obtaining data that could help to explain the link between obesity and its related cardiometabolic complications. We defined metabolic health in terms of several metabolic and inflammatory risk factors. The serum adiponectin levels were higher in the healthy group and showed a positive correlation with HDL cholesterol levels in the unhealthy group. There were no differences between the two groups in the levels of serum leptin, chemerin and orosomucoid. Accordingly, adiponectin might play a role in protecting against obesity-associated cardiometabolic derangements. More studies are needed to clarify the role of different chemerin isoforms in this system.http://dx.doi.org/10.1155/2014/170434 |
| spellingShingle | Assim A. Alfadda Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects International Journal of Endocrinology |
| title | Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects |
| title_full | Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects |
| title_fullStr | Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects |
| title_full_unstemmed | Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects |
| title_short | Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects |
| title_sort | circulating adipokines in healthy versus unhealthy overweight and obese subjects |
| url | http://dx.doi.org/10.1155/2014/170434 |
| work_keys_str_mv | AT assimaalfadda circulatingadipokinesinhealthyversusunhealthyoverweightandobesesubjects |