Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance
Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and...
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| Format: | Article |
| Language: | English |
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2017-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0036 |
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| author | Pajić Nataša Z. Bubić Todosijević Marija N. Vuleta Gordana M. Cekić Nebojša D. Dobričić Vladimir D. Vučen Sonja R. Čalija Bojan R. Lukić Milica Ž. Ilić Tanja M. Savić Snežana D. |
| author_facet | Pajić Nataša Z. Bubić Todosijević Marija N. Vuleta Gordana M. Cekić Nebojša D. Dobričić Vladimir D. Vučen Sonja R. Čalija Bojan R. Lukić Milica Ž. Ilić Tanja M. Savić Snežana D. |
| author_sort | Pajić Nataša Z. Bubić |
| collection | DOAJ |
| description | Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/ caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth- 7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs. |
| format | Article |
| id | doaj-art-f0d853dcae9d46839010582cda5d9e5f |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-f0d853dcae9d46839010582cda5d9e5f2025-02-02T00:31:54ZengSciendoActa Pharmaceutica1846-95582017-12-0167441543910.1515/acph-2017-0036acph-2017-0036Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performancePajić Nataša Z. Bubić0Todosijević Marija N.1Vuleta Gordana M.2Cekić Nebojša D.3Dobričić Vladimir D.4Vučen Sonja R.5Čalija Bojan R.6Lukić Milica Ž.7Ilić Tanja M.8Savić Snežana D.9Department of Pharmaceutical Technology and Cosmetology Faculty of Medicine, University of Banja Luka, 78000 Banja LukaBosnia and HerzegovinaDepartment of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, SerbiaFaculty of Technology, University of Niš, 16000 Leskovac, SerbiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy University of Belgrade, Belgrade, SerbiaSchool of Pharmacy, University College Cork, Cork, IrelandDepartment of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, SerbiaTwo types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/ caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth- 7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.https://doi.org/10.1515/acph-2017-0036alkyl polyglucosideethoxylated surfactantadapalenesertaconazole nitratebiocompatible microemulsionin vivo skin irritation |
| spellingShingle | Pajić Nataša Z. Bubić Todosijević Marija N. Vuleta Gordana M. Cekić Nebojša D. Dobričić Vladimir D. Vučen Sonja R. Čalija Bojan R. Lukić Milica Ž. Ilić Tanja M. Savić Snežana D. Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance Acta Pharmaceutica alkyl polyglucoside ethoxylated surfactant adapalene sertaconazole nitrate biocompatible microemulsion in vivo skin irritation |
| title | Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance |
| title_full | Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance |
| title_fullStr | Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance |
| title_full_unstemmed | Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance |
| title_short | Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance |
| title_sort | alkyl polyglucoside vs ethoxylated surfactant based microemulsions as vehicles for two poorly water soluble drugs physicochemical characterization and in vivo skin performance |
| topic | alkyl polyglucoside ethoxylated surfactant adapalene sertaconazole nitrate biocompatible microemulsion in vivo skin irritation |
| url | https://doi.org/10.1515/acph-2017-0036 |
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