High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition

High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition

Abstract Bone marrow fibrosis (BMF) impairs normal hematopoietic functions in patients. The overactivation of the TGF-β signaling pathway is regarded as one of the offenders causing disease progression. Thus, factors capable of regulating TGF-β secretion hold great potential in reversing fibrotic di...

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Main Authors: Chiao-Hsu Ke, Mao-En Huang, Hsin-Yi Wu, Chao-Wu Yu, Shuei-Liong Lin, Shau-Ping Lin, Shu-Han Yu, Chih-Hung Huang, Chen-Si Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Bone marrow fibrosis
Histone deacetylase inhibitor
Transforming growth factor-β (TGF-β)
Organ fibrosis
Online Access:https://doi.org/10.1038/s41598-025-08384-6
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https://doi.org/10.1038/s41598-025-08384-6

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