The Role of PPARs in the Endothelium: Implications for Cancer Therapy
The growth and metastasis of cancers intimately involve the vasculature and in particular the endothelial cell layer. Tumours require new blood vessel formation via angiogenesis to support growth. In addition, inflammation, coagulation, and platelet activation are common signals in the growth and me...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/904251 |
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| _version_ | 1832555573086781440 |
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| author | David Bishop-Bailey Karen E. Swales |
| author_facet | David Bishop-Bailey Karen E. Swales |
| author_sort | David Bishop-Bailey |
| collection | DOAJ |
| description | The growth and metastasis of cancers intimately involve the vasculature and in particular the endothelial cell layer. Tumours require new blood vessel formation via angiogenesis to support growth. In addition, inflammation, coagulation, and platelet activation are common signals in the growth and metastasis of tumour cells. The endothelium plays a central role in the homeostatic control of inflammatory cell recruitment, regulating platelet activation and coagulation pathways. PPAR𝛼, -𝛽/𝛿, and -𝛾 are all expressed in endothelial cells. This review will discuss the roles of PPARs in endothelial cells in relation to angiogenesis, inflammation, coagulation, and platelet control pathways. In particular, we will discuss the recent evidence that supports the hypothesis that PPAR𝛼 and PPAR𝛾 are antiangiogenic receptors, while PPAR𝛽/𝛿 is proangiogenic. |
| format | Article |
| id | doaj-art-f06b5da9c2e841a28ae26c9769c3aa07 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-f06b5da9c2e841a28ae26c9769c3aa072025-02-03T05:47:51ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/904251904251The Role of PPARs in the Endothelium: Implications for Cancer TherapyDavid Bishop-Bailey0Karen E. Swales1Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UKTranslational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UKThe growth and metastasis of cancers intimately involve the vasculature and in particular the endothelial cell layer. Tumours require new blood vessel formation via angiogenesis to support growth. In addition, inflammation, coagulation, and platelet activation are common signals in the growth and metastasis of tumour cells. The endothelium plays a central role in the homeostatic control of inflammatory cell recruitment, regulating platelet activation and coagulation pathways. PPAR𝛼, -𝛽/𝛿, and -𝛾 are all expressed in endothelial cells. This review will discuss the roles of PPARs in endothelial cells in relation to angiogenesis, inflammation, coagulation, and platelet control pathways. In particular, we will discuss the recent evidence that supports the hypothesis that PPAR𝛼 and PPAR𝛾 are antiangiogenic receptors, while PPAR𝛽/𝛿 is proangiogenic.http://dx.doi.org/10.1155/2008/904251 |
| spellingShingle | David Bishop-Bailey Karen E. Swales The Role of PPARs in the Endothelium: Implications for Cancer Therapy PPAR Research |
| title | The Role of PPARs in the Endothelium: Implications for Cancer Therapy |
| title_full | The Role of PPARs in the Endothelium: Implications for Cancer Therapy |
| title_fullStr | The Role of PPARs in the Endothelium: Implications for Cancer Therapy |
| title_full_unstemmed | The Role of PPARs in the Endothelium: Implications for Cancer Therapy |
| title_short | The Role of PPARs in the Endothelium: Implications for Cancer Therapy |
| title_sort | role of ppars in the endothelium implications for cancer therapy |
| url | http://dx.doi.org/10.1155/2008/904251 |
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