Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study
Abstract Breast cancer is the most common cancer among women, with over 1 million new cases and around 400,000 deaths annually worldwide. This makes it a significant and costly global health challenge. Standard treatments like chemotherapy and radiotherapy, often used after mastectomy, show varying...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Nano |
| Online Access: | https://doi.org/10.1186/s11671-025-04186-x |
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| author | Simona Tarantino Annalisa Bianco Mariafrancesca Cascione Alessandra Carlà Lia Fiamà Riccardo Di Corato Livia Giotta Paolo Pellegrino Anna Paola Caricato Rosaria Rinaldi Valeria De Matteis |
| author_facet | Simona Tarantino Annalisa Bianco Mariafrancesca Cascione Alessandra Carlà Lia Fiamà Riccardo Di Corato Livia Giotta Paolo Pellegrino Anna Paola Caricato Rosaria Rinaldi Valeria De Matteis |
| author_sort | Simona Tarantino |
| collection | DOAJ |
| description | Abstract Breast cancer is the most common cancer among women, with over 1 million new cases and around 400,000 deaths annually worldwide. This makes it a significant and costly global health challenge. Standard treatments like chemotherapy and radiotherapy, often used after mastectomy, show varying effectiveness based on the cancer subtype. Combining these treatments can improve outcomes, though radiotherapy faces limitations such as radiation resistance and low selectivity for malignant cells. Nanotechnologies, especially metallic nanoparticles (NPs), hold promise for enhancing radiotherapy. Gold nanoparticles (AuNPs) are particularly notable due to their high atomic number, which enhances radiation damage through the photoelectric effect. Studies shown that AuNPs can act as effective radiosensitizers, improving tumor damage during radiotherapy increasing the local radiation dose delivered. Traditional AuNPs synthesis methods involve harmful chemicals and extreme conditions, posing health risks. Green synthesis methods using plant extracts offer a safer and more environmentally friendly alternative. This study investigates the synthesis of AuNPs using Laurus nobilis leaf extract and their potential as radiosensitizers in breast carcinoma cell lines (MCF-7). These cells were exposed to varying doses of X-ray irradiation, and the study assessed cell viability, morphological changes and DNA damage. The results showed that green-synthesized AuNPs significantly enhanced the therapeutic effects of radiotherapy at lower radiation doses, indicating their potential as a valuable addition to breast cancer treatment. |
| format | Article |
| id | doaj-art-f04149e4b2d94fabbb06a1efc6da4ac5 |
| institution | Kabale University |
| issn | 2731-9229 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj-art-f04149e4b2d94fabbb06a1efc6da4ac52025-01-19T12:36:20ZengSpringerDiscover Nano2731-92292025-01-0120112010.1186/s11671-025-04186-xRevolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro studySimona Tarantino0Annalisa Bianco1Mariafrancesca Cascione2Alessandra Carlà3Lia Fiamà4Riccardo Di Corato5Livia Giotta6Paolo Pellegrino7Anna Paola Caricato8Rosaria Rinaldi9Valeria De Matteis10Department of Mathematics and Physics “Ennio De Giorgi”, University of SalentoDepartment of Mathematics and Physics “Ennio De Giorgi”, University of SalentoDepartment of Mathematics and Physics “Ennio De Giorgi”, University of SalentoOncological Center, “Vito Fazzi” Hospital of LecceOncological Center, “Vito Fazzi” Hospital of LecceInstitute for Microelectronics and Microsystems (IMM), CNRDepartment of Biological and Environmental Sciences and Technologies (DiSTeBA), University of SalentoInstitute for Microelectronics and Microsystems (IMM), CNRDepartment of Mathematics and Physics “Ennio De Giorgi”, University of SalentoDepartment of Mathematics and Physics “Ennio De Giorgi”, University of SalentoDepartment of Mathematics and Physics “Ennio De Giorgi”, University of SalentoAbstract Breast cancer is the most common cancer among women, with over 1 million new cases and around 400,000 deaths annually worldwide. This makes it a significant and costly global health challenge. Standard treatments like chemotherapy and radiotherapy, often used after mastectomy, show varying effectiveness based on the cancer subtype. Combining these treatments can improve outcomes, though radiotherapy faces limitations such as radiation resistance and low selectivity for malignant cells. Nanotechnologies, especially metallic nanoparticles (NPs), hold promise for enhancing radiotherapy. Gold nanoparticles (AuNPs) are particularly notable due to their high atomic number, which enhances radiation damage through the photoelectric effect. Studies shown that AuNPs can act as effective radiosensitizers, improving tumor damage during radiotherapy increasing the local radiation dose delivered. Traditional AuNPs synthesis methods involve harmful chemicals and extreme conditions, posing health risks. Green synthesis methods using plant extracts offer a safer and more environmentally friendly alternative. This study investigates the synthesis of AuNPs using Laurus nobilis leaf extract and their potential as radiosensitizers in breast carcinoma cell lines (MCF-7). These cells were exposed to varying doses of X-ray irradiation, and the study assessed cell viability, morphological changes and DNA damage. The results showed that green-synthesized AuNPs significantly enhanced the therapeutic effects of radiotherapy at lower radiation doses, indicating their potential as a valuable addition to breast cancer treatment.https://doi.org/10.1186/s11671-025-04186-x |
| spellingShingle | Simona Tarantino Annalisa Bianco Mariafrancesca Cascione Alessandra Carlà Lia Fiamà Riccardo Di Corato Livia Giotta Paolo Pellegrino Anna Paola Caricato Rosaria Rinaldi Valeria De Matteis Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study Discover Nano |
| title | Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study |
| title_full | Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study |
| title_fullStr | Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study |
| title_full_unstemmed | Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study |
| title_short | Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study |
| title_sort | revolutionizing radiotherapy gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells an in vitro study |
| url | https://doi.org/10.1186/s11671-025-04186-x |
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