Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia
In protracted myocardial ischemia, sympathetic activation with carrier-mediated excessive norepinephrine (NE) release from its nerve endings due to reversal of NE transporter in an outward direction is a prominent cause of arrhythmias and cardiac dysfunction. Endothelin-1 (ET-1) and its receptors ar...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/789071 |
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| _version_ | 1832564022801596416 |
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| author | Masashi Tawa Satoshi Yamamoto Mamoru Ohkita Yasuo Matsumura |
| author_facet | Masashi Tawa Satoshi Yamamoto Mamoru Ohkita Yasuo Matsumura |
| author_sort | Masashi Tawa |
| collection | DOAJ |
| description | In protracted myocardial ischemia, sympathetic activation with carrier-mediated excessive norepinephrine (NE) release from its nerve endings due to reversal of NE transporter in an outward direction is a prominent cause of arrhythmias and cardiac dysfunction. Endothelin-1 (ET-1) and its receptors are intimately involved in the regulation of this carrier-mediated NE overflow in protracted myocardial ischemia. The ET-1 system is often complex, sometimes involving opposing actions depending on which receptor subtype is activated, which cells are affected, and whether stimuli are endogenously generated or exogenously applied. Therefore, a detailed understanding of the ET-1 system is important for applying drugs acting on this system in clinical settings for the treatment of ischemic cardiac disease. This article provides a detailed analysis of how the ET-1 system is involved in the regulation of carrier-mediated NE release from sympathetic nerve endings in protracted myocardial ischemia. |
| format | Article |
| id | doaj-art-f03b7af07b164eddbaace80e8e88d21d |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-f03b7af07b164eddbaace80e8e88d21d2025-02-03T01:12:03ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/789071789071Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial IschemiaMasashi Tawa0Satoshi Yamamoto1Mamoru Ohkita2Yasuo Matsumura3Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, JapanLaboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, JapanLaboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, JapanLaboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, JapanIn protracted myocardial ischemia, sympathetic activation with carrier-mediated excessive norepinephrine (NE) release from its nerve endings due to reversal of NE transporter in an outward direction is a prominent cause of arrhythmias and cardiac dysfunction. Endothelin-1 (ET-1) and its receptors are intimately involved in the regulation of this carrier-mediated NE overflow in protracted myocardial ischemia. The ET-1 system is often complex, sometimes involving opposing actions depending on which receptor subtype is activated, which cells are affected, and whether stimuli are endogenously generated or exogenously applied. Therefore, a detailed understanding of the ET-1 system is important for applying drugs acting on this system in clinical settings for the treatment of ischemic cardiac disease. This article provides a detailed analysis of how the ET-1 system is involved in the regulation of carrier-mediated NE release from sympathetic nerve endings in protracted myocardial ischemia.http://dx.doi.org/10.1155/2012/789071 |
| spellingShingle | Masashi Tawa Satoshi Yamamoto Mamoru Ohkita Yasuo Matsumura Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia Cardiology Research and Practice |
| title | Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia |
| title_full | Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia |
| title_fullStr | Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia |
| title_full_unstemmed | Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia |
| title_short | Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia |
| title_sort | endothelin 1 and norepinephrine overflow from cardiac sympathetic nerve endings in myocardial ischemia |
| url | http://dx.doi.org/10.1155/2012/789071 |
| work_keys_str_mv | AT masashitawa endothelin1andnorepinephrineoverflowfromcardiacsympatheticnerveendingsinmyocardialischemia AT satoshiyamamoto endothelin1andnorepinephrineoverflowfromcardiacsympatheticnerveendingsinmyocardialischemia AT mamoruohkita endothelin1andnorepinephrineoverflowfromcardiacsympatheticnerveendingsinmyocardialischemia AT yasuomatsumura endothelin1andnorepinephrineoverflowfromcardiacsympatheticnerveendingsinmyocardialischemia |