紫云英苷诱导自噬减轻APP/PS1转基因小鼠皮质内神经元损伤及老年斑沉积
目的探讨紫云英苷(AST)对APP/PS1转基因小鼠脑皮质神经元及Aβ斑块的影响。方法将24只8月龄雄性APP/PS1转基因小鼠随机分为APP/PS1组、10 mg/kg AST(APP/PS1+AST 10)组、20 mg/kg AST(APP/PS1+AST 20)组、40 mg/kg AST(APP/PS1+AST 40)组,每组各6只。6只同月龄C57BL/6雄性小鼠作为对照组(WT组)。AST药物连续腹腔注射一个月后,采用免疫荧光染色法观察小鼠脑皮质内Aβ斑块沉积情况,尼氏染色法观察皮质内神经元数量及形态变化,免疫荧光多重染色法观察小鼠脑皮质内LC3B、p62分别与NeuN共表达情况...
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Main Authors: | , , , , , , |
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Format: | Article |
Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2022-03-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
Subjects: | |
Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0209/ |
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