Ceftolozane/tazobactam use and emergence of resistance: a 4-year analysis of antimicrobial susceptibility in Pseudomonas aeruginosa isolates in a tertiary hospital

Ceftolozane/tazobactam use and emergence of resistance: a 4-year analysis of antimicrobial susceptibility in Pseudomonas aeruginosa isolates in a tertiary hospital

BackgroundCeftolozane/tazobactam (C/T) was temporarily withdrawn from December 2020 to February 2022: this forced unavailability created the conditions to study how drug discontinuation might influence Pseudomonas aeruginosa (PA) resistance reversibility in a real-life setting.MethodsClinically rele...

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Main Authors: Alessandra Imeneo, Laura Campogiani, Pietro Vitale, Andrea Di Lorenzo, Grazia Alessio, Davide Natale Abate, Maria Grazia Celeste, Anna Altieri, Cartesio D’Agostini, Vincenzo Malagnino, Massimo Andreoni, Marco Iannetta, Loredana Sarmati
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
ceftolozane/tazobactam
Pseudomonas aeruginosa
fitness-cost
resistance
antibiotic susceptibility testing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1542491/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1542491/full

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