Synaptic vesicle characterization of iPSC-derived dopaminergic neurons provides insight into distinct secretory vesicle pools

Abstract The dysfunction of dopaminergic (DA) neurons is central to Parkinson’s disease. Distinct synaptic vesicle (SV) populations, differing in neurotransmitter content (dopamine vs. glutamate), may vary due to differences in trafficking and exocytosis. However, the structural organization of thes...

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Bibliographic Details
Main Authors: Kenshiro Fujise, Jaya Mishra, Martin Shaun Rosenfeld, Nisha Mohd Rafiq
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00862-4
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