Gelsolin-mediated actin filament severing, mechanics, and conformational changes at neutral and acidic pH

Gelsolin-mediated actin filament severing, mechanics, and conformational changes at neutral and acidic pH

Gelsolin is a calcium (Ca2+) dependent, pH sensitive actin-binding protein that regulates actin filament dynamics to remodel the actin cytoskeleton. It is known that gelsolin binding induces conformational changes of actin filaments, leading to filament severing. However, the influence of physiologi...

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Bibliographic Details
Main Authors:	Taylor V. Douglas, Claire A. Toland, Sydney A. Paulin, Nicholas Castaneda, Laurene Tetard, Ellen H. Kang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Soft Matter
Subjects:	actin cytoskeleton gelsolin severing bending mechanics filament conformation intracellular pH
Online Access:	https://www.frontiersin.org/articles/10.3389/frsfm.2025.1530439/full
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