Dioscin regulates oxidative stress and autophagy in uric acid-induced HK-2 cells through the P62-KEAP1-NRF2 signaling pathway
Abstract Objective This study aims to explore the therapeutic effects and mechanisms of dioscin on the UA-induced HK-2 cells fibrosis model by modulating oxidative stress and autophagy. Methods HK-2 cells fibrosis was constructed by UA stimulation. CCK8 was used to assess cell proliferation. Flow cy...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-025-04311-z |
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