Deciphering direct transcriptional effects of epigenetic compounds through large-scale new RNA profiling

Deciphering direct transcriptional effects of epigenetic compounds through large-scale new RNA profiling

Abstract Examining direct transcriptional effects of genetic and chemical perturbations is crucial for understanding gene expression mechanisms. Standard RNA-seq experiments often overlook these direct effects, and current methods for profiling nascent RNA are usually time-consuming. Here, we adapte...

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Main Authors: Leonard Hartmanis, Daniel Ramsköld, Gert-Jan Hendriks, Per Johnsson, Gustav Hallén, Ran Ma, Anton J. M. Larsson, Salomé Hahne, Christoph Ziegenhain, Johan Hartman, Rickard Sandberg
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61769-z
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https://doi.org/10.1038/s41467-025-61769-z

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