Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential

Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential

Malaria, caused by <i>Plasmodium</i> species and transmitted by <i>Anopheles</i> mosquitoes, continues to pose a significant global health threat. Pipecolisporin, a cyclic hexapeptide isolated from <i>Nigrospora oryzae</i>, has emerged as a promising antimalarial...

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Bibliographic Details
Main Authors: Nety Kurniaty, Taufik Muhammad Fakih, Rani Maharani, Unang Supratman, Ace Tatang Hidayat, Nurhidanatasha Abu Bakar, Xiaoshuang Wei
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
pipecolisporin
cyclic hexapeptide
solid-phase peptide synthesis (SPPS)
antimalarial candidates
computational studies
Online Access:https://www.mdpi.com/1420-3049/30/2/304
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