Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma

Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma

Abstract De novo purine biosynthesis (DNPS) was previously shown to be aberrantly activated in many cancers. However, the activity of DNPS pathway and its underlying regulatory mechanism in hepatoblastoma (HB) remain poorly understood. Herein, we discovered that the expression of PPAT, the rate-limi...

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Main Authors: Ming Ding, Chunshuang Ma, Yanyan Lin, Houshun Fang, Yan Xu, Shuxuan Wang, Yao Chen, Jiquan Zhou, Hongxiang Gao, Yuhua Shan, Liyuan Yang, Huiying Sun, Yabin Tang, Xiaoyu Wu, Liang Zhu, Liang Zheng, Yehuda G. Assaraf, Bin-Bing S. Zhou, Song Gu, Hui Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07502-6
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https://doi.org/10.1038/s41419-025-07502-6

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