Staphylococcus aureus thermonuclease NucA is a key virulence factor in septic arthritis

Abstract Septic arthritis, primarily caused by Staphylococcus aureus, poses a significant risk of both mortality and morbidity due to its aggressive nature. The nuc1-encoded thermonuclease NucA of S. aureus degrades extracellular DNA/RNA, allowing the pathogen to escape neutrophil extracellular trap...

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Bibliographic Details
Main Authors: Ningna Li, Meghshree Vinod Deshmukh, Filiz Sahin, Nourhane Hafza, Aparna Viswanathan Ammanath, Sabrina Ehnert, Andreas Nüssler, Alexander N. R. Weber, Tao Jin, Friedrich Götz
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07920-4
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