Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi
This case report presents a 40-year-old transgender female with a history of gender-affirming hormone therapy who experienced recurrent, medication-resistant arterial thrombi leading to bilateral lower extremity amputations. Despite multiple endovascular and surgical interventions, including bypass...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Vascular Surgery Cases and Innovative Techniques |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468428724002399 |
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| author | Mitchell C. McDaniels, BS Patrick D. Conroy, MD Philip M. Batista, MD |
| author_facet | Mitchell C. McDaniels, BS Patrick D. Conroy, MD Philip M. Batista, MD |
| author_sort | Mitchell C. McDaniels, BS |
| collection | DOAJ |
| description | This case report presents a 40-year-old transgender female with a history of gender-affirming hormone therapy who experienced recurrent, medication-resistant arterial thrombi leading to bilateral lower extremity amputations. Despite multiple endovascular and surgical interventions, including bypass grafting and catheter-directed thrombolysis, the patient developed recurrent thrombotic events even while on anticoagulation therapy. Hematologic evaluation for coagulopathy was unremarkable. The case underscores the need for greater understanding of gender-affirming hormone therapy’s long-term cardiovascular effects while highlighting the challenges in managing arterial thrombosis in transgender patients. Further research is required to guide optimal anticoagulation strategies in this population. |
| format | Article |
| id | doaj-art-efa5f09863454e0598bc4e8555b76f78 |
| institution | Kabale University |
| issn | 2468-4287 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Vascular Surgery Cases and Innovative Techniques |
| spelling | doaj-art-efa5f09863454e0598bc4e8555b76f782025-01-20T04:17:41ZengElsevierJournal of Vascular Surgery Cases and Innovative Techniques2468-42872025-02-01111101655Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombiMitchell C. McDaniels, BS0Patrick D. Conroy, MD1Philip M. Batista, MD2Department of Vascular and Endovascular Surgery, Cooper University Hospital, Camden, NJCorrespondence: Patrick D. Conroy, MD, Cooper University Hospital, 3 Cooper Plaza, Ste 411, Camden, NJ 08103; Department of Vascular and Endovascular Surgery, Cooper University Hospital, Camden, NJDepartment of Vascular and Endovascular Surgery, Cooper University Hospital, Camden, NJThis case report presents a 40-year-old transgender female with a history of gender-affirming hormone therapy who experienced recurrent, medication-resistant arterial thrombi leading to bilateral lower extremity amputations. Despite multiple endovascular and surgical interventions, including bypass grafting and catheter-directed thrombolysis, the patient developed recurrent thrombotic events even while on anticoagulation therapy. Hematologic evaluation for coagulopathy was unremarkable. The case underscores the need for greater understanding of gender-affirming hormone therapy’s long-term cardiovascular effects while highlighting the challenges in managing arterial thrombosis in transgender patients. Further research is required to guide optimal anticoagulation strategies in this population.http://www.sciencedirect.com/science/article/pii/S2468428724002399Acute limb ischemiaArterial thrombiEstrogen therapyGender-affirming hormone therapy (GAHT)Transgender |
| spellingShingle | Mitchell C. McDaniels, BS Patrick D. Conroy, MD Philip M. Batista, MD Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi Journal of Vascular Surgery Cases and Innovative Techniques Acute limb ischemia Arterial thrombi Estrogen therapy Gender-affirming hormone therapy (GAHT) Transgender |
| title | Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi |
| title_full | Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi |
| title_fullStr | Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi |
| title_full_unstemmed | Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi |
| title_short | Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi |
| title_sort | bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent medication resistant arterial thrombi |
| topic | Acute limb ischemia Arterial thrombi Estrogen therapy Gender-affirming hormone therapy (GAHT) Transgender |
| url | http://www.sciencedirect.com/science/article/pii/S2468428724002399 |
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