Exploring the impact of SerpinA3n deficiency on prion strains propagation

Exploring the impact of SerpinA3n deficiency on prion strains propagation

Transmissible spongiform encephalopathies (TSEs) are a group of devastating neurodegenerative diseases characterized by the conversion of the normal cellular prion protein (PrPC) into its misfolded, pathogenic form, PrPSc. Despite significant research, the exact molecular mechanisms driving PrPC to...

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Main Authors: Fabio Moda, Chiara Ferracin, Ilaria Linda Dellarole, Edoardo Bistaffa, Chiara Maria Giulia De Luca, Marco Zattoni, Diletta Giovanna Legari, Lea Nikolic, Anna Burato, Martina Brce, Giuseppe Bufano, Merve Begüm Bacınoğlu, Federico Angelo Cazzaniga, Tihana Lenac Rovis, Giuseppe Legname
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neurobiology of Disease
Subjects:
Prion diseases
Serpin
SerpinA3n
SERPINA3
PMCA
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001895
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