Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism.

Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism.

While SARS-CoV-2 primarily infects the respiratory tract, clinical evidence indicates that cells from diverse cell types and organs are also susceptible to infection. Using the CRISPR activation (CRISPRa) approach, we systematically targeted human membrane proteins in cells with and without overexpr...

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Main Authors: Ravi K Dinesh, Chengkun Wang, Yuanhao Qu, Arjun Rustagi, Henry Cousins, James Zengel, Xiaotong Wang, Trisha R Barnard, William A Johnson, Guangxue Xu, Tianyi Zhang, Nicholas Magazine, Aimee Beck, Lucas Miecho Heilbroner, Grace Peters-Schulze, Aaron J Wilk, Mengdi Wang, Weishan Huang, Brooke E Howitt, Jan Carette, Russ Altman, Catherine A Blish, Le Cong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013157
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https://doi.org/10.1371/journal.ppat.1013157

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