SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

Summary: Impaired neuronal and synaptic function are hallmarks of early Alzheimer’s disease (AD), preceding other neuropathological traits and cognitive decline. We previously showed that SFRP1, a glial-derived protein elevated in AD brains from preclinical stages, contributes to disease progression...

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Main Authors: Guadalupe Pereyra, María Inés Mateo, Pablo Miaja, María Jesús Martin-Bermejo, Marcos Martinez-Baños, Remco Klaassen, Agnès Gruart, Javier Rueda-Carrasco, Alba Fernández-Rodrigo, Esperanza López-Merino, Pilar Esteve, José A. Esteban, August B. Smit, José M. Delgado-García, Paola Bovolenta
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003067
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