Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer’s disease

Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer’s disease

Abstract Sleep alterations are known to occur in Alzheimer’s disease (AD), before cognitive symptoms become apparent, and are thought to play an important role in the pathophysiology of AD. However, knowledge on the extent of macro- and microstructural changes of sleep during early, presymptomatic s...

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Main Authors: Monica van den Berg, Loran Heymans, Daniëlle Toen, Mohit A. Adhikari, Johan Van Audekerke, Marlies Verschuuren, Isabel Pintelon, Winnok H. De Vos, Annemie Van der Linden, Marleen Verhoye, Georgios A. Keliris
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Hippocampal local field potentials
REM sleep
NREM sleep
Sharp wave-ripples
Phase-amplitude coupling
TgF344-AD
Online Access:https://doi.org/10.1186/s40478-025-02016-w
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https://doi.org/10.1186/s40478-025-02016-w

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