Immunotherapeutic Blockade of CD47 Increases Virus Neutralization Antibodies

Immunotherapeutic Blockade of CD47 Increases Virus Neutralization Antibodies

Background/Objectives: CD47 is a cell surface glycoprotein moderately expressed in healthy cells and upregulated in cancer and viral infected cells. CD47’s interaction with signal regulatory protein alpha (SIRPα) inhibits phagocytic cells and its interaction with thrombospondin-1 inhibits T cell res...

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Bibliographic Details
Main Authors: Lamin B. Cham, Thamer A. Hamdan, Hilal Bhat, Bello Sirajo, Murtaza Ali, Khaled Saeed Tabbara, Eman Farid, Mohamed-Ridha Barbouche, Tom Adomati
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
CD47
VSV
immunotherapy
antibodies
vaccines
Online Access:https://www.mdpi.com/2076-393X/13/6/602
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