Synthesis of extended fluorinated tripeptides based on the tetrahydropyridazine scaffold

The synthesis of tripeptides incorporating new fluorinated heterocyclic hydrazino acids, based on the tetrahydropyridazine scaffold is described. Starting from simple fluorinated hydrazones, these non-proteinogenic cyclic β-amino acids were easily prepared by a zinc-catalyzed aza-Barbier reaction fo...

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Bibliographic Details
Main Authors: Thierry Milcent, Pascal Retailleau, Benoit Crousse, Sandrine Ongeri
Format: Article
Language:English
Published: Beilstein-Institut 2024-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.20.262
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