Lactate transporter MCT4 regulates the hub genes for lipid metabolism and inflammation to attenuate intracellular lipid accumulation in non-alcoholic fatty liver disease

Lactate transporter MCT4 regulates the hub genes for lipid metabolism and inflammation to attenuate intracellular lipid accumulation in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) patients have multiple metabolic disturbances, with markedly elevated levels of lactate. Lactate accumulations play pleiotropic roles in disease progression through metabolic rearrangements and epigenetic modifications. Monocarboxylate transporter 4 (MCT4) i...

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Bibliographic Details
Main Authors: Yannian Gou, Aohua Li, Xiangyu Dong, Ailing Hao, Jiajia Li, Han Xiang, Saidur Rahaman, Tong-Chuan He, Jiaming Fan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-07-01
Series:Genes and Diseases
Subjects:
Hepatic steatosis
Lactate
Lipid metabolism
Monocarboxylate transporter 4 (MCT4)
Non-alcoholic fatty liver disease (NAFLD)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225000431
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