Cerebrospinal fluid Circulating Tumor DNA (ctDNA) as a biomarker for CNS metastases in Non-Small Cell Lung Cancer (NSCLC): a systematic review and meta-analysis comparing CSF ctDNA and traditional methods

Cerebrospinal fluid Circulating Tumor DNA (ctDNA) as a biomarker for CNS metastases in Non-Small Cell Lung Cancer (NSCLC): a systematic review and meta-analysis comparing CSF ctDNA and traditional methods

Abstract Background Brain metastasis is a common and serious complication in patients with non-small cell lung cancer (NSCLC), often associated with poor prognosis. While traditional diagnostic approaches such as magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology are commonly us...

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Bibliographic Details
Main Authors: Oluwatobi O. Olayode, Blessing T. Ogunoye, Emmanuel Olusola Oladeji, Oluwafemi E. Olayinka, Tolulope J. Oladosu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
CSF ctDNA
Brain metastases
NSCLC
Liquid biopsy
Diagnostic accuracy
Biomarker
Online Access:https://doi.org/10.1186/s12885-025-14583-1
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https://doi.org/10.1186/s12885-025-14583-1

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