Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

During aging, microglia – the resident macrophages of the brain – exhibit altered phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks of age-related microglia have been elucidated, the progression from homeostasis to dysfunction during the aging process remains unres...

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Bibliographic Details
Main Authors: Jeremy M Shea, Saul A Villeda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/97671
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