Histidine triad nucleotide‐binding protein 2 attenuates doxorubicin‐induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice

Histidine triad nucleotide‐binding protein 2 attenuates doxorubicin‐induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice

Abstract Doxorubicin (DOX) is an effective chemotherapy drug widely used against various cancers but is limited by severe cardiotoxicity. Mitochondria–lysosome interactions are crucial for cellular homeostasis. This study investigates the role of histidine triad nucleotide‐binding protein 2 (HINT2)...

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Main Authors: Hao Jiang, Jinyan Zhang, Daile Jia, Liwei Liu, Jinfeng Gao, Beijian Zhang, Zhen Dong, Xiaolei Sun, Wenlong Yang, Tiantong Ou, Suling Ding, Luna He, Yiqin Shi, Kai Hu, Aijun Sun, Junbo Ge
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:MedComm
Subjects:
autophagy
doxorubicin
HINT2
lysosome
NAD+/NADH
Online Access:https://doi.org/10.1002/mco2.70075
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https://doi.org/10.1002/mco2.70075

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